UNICEF heads three UN Clusters coordinating relief and rehabilitation activities: WATSAN, Education and Child Protection. In addition to its program activities in these three sectors, as well as in Health, UNICEF is also playing a lead role in the communication response to the earthquake.

WHO heads the UN Health Cluster in the earthquake response and is carrying out various health-related activities as a part of relief and rehabilitation efforts.

The Humanitarian Information Centre (HIC) for Pakistan is a common service to the humanitarian community managed by the United Nations Office for the Coordination of Humanitarian Affairs (UN OCHA).

The Federal Relief Commission was established to plan, coordinate, direct and monitor all relief efforts. All Govt Agencies including Armed Forces concerned with the relief efforts shall function through FRC.

Working with local partners Oxfam is supplying emergency aid, including extensive efforts for Hygiene, Water and Sanitation, to thousands affected by the earthquake.

Islamic Relief's work is heavily focused on the areas that have been badly affected by this disaster, including Muzaffarabad and Bagh where Islamic Relief has several projects, including on Hygiene, Water and Sanitation.

Concern teams are working with the UN and other agencies based in Pakistan to bring relief to areas affected by the earthquake, including projects on Hygiene, Water and Sanitation.

Despite losing many Scouts and leaders in the earthquake, the Pakistan Boy Scouts Association has been involved in the earthquake response since October 8, including deploying teams of Scouts from all over Pakistan to raise awareness on hygiene, water and sanitation and other health issues in the affected areas.